SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

Project area A includes all projects that study Mediators and Effectors that act on the cells of the vessel wall. These are: 

A2: Chavakis/Dimmeler
Role of integrin activity regulation for endothelial cell adhesion, migration and angiogenesis

A3: Augustin 
Role of the Angiopoietin/Tie system in controlling vascular morphogenesis and homeostasis

A4: Schmidt
Regulation of vascular Notch signaling by EGFL7

A6: Fleming
Molecular analysis of cytochrome P450 epoxygenases as regulators of angiogenic endothelial cell signaling and vascular differentiation

A7: Fischer
The role of Notch ligands during blood vessel development

A8: Eble
Physiological roles of collagen-binding integrins on endothelial cells in angiogenic sprouting and vessel integrity

A9: Schneider
Mechanism controlling the transition from quiescent to activated endothelium by exocytosis of Weibel-Palade bodies triggered by tumor cells

Project area B includes all projects that study Cellular Responses of the cells of the vessel wall. These are: 

B1: Goerdt
Differentiation and remodeling of hepatic sinusoidal endothelium in homeostasis and dysfunction

B2: Schorpp-Kistner/Angel
Role of Junb and Junb target genes in endothelial cell function and tumor angiogenesis  

B5: Urbich
Role of histone deacetylases (HDACs) for angiogenesis signaling in endothelial cells

B6: Wieland/Lutz
Endothelial RhoGEFs as regulators of angiogenesis

B7: Liebner/Plate
Molecular analysis of the Wnt/β-catenin pathway in endothelial differentiation and remodeling

Project area C includes all projects that study Cellular and Systemic Interactions between the cells of the vessel wall. These are:

C1: Reiss/Plate
Influence of Angiopoietin-2 on vascular integrity and accessory cell recruitment

C5: Korff
The role of smooth muscle cells during stretch-induced vascular remodeling

C6: Hecker
Endothelial cell-platelet-leukocyte interaction in vascular remodeling:
Role of CD40/CD154-mediated co-stimulation

C7: Wettschureck/Offermanns
Mechanisms of platelet activation and their relevance for platelet / vessel wall interaction

Project area Z - Core Projects

Z1: Bäuerle/Müller
Non-invasive assessment of tissue micro-morphology, vessel function and cell migration in vivo with contrast-enhanced MRI, VCT and sonography

Z5: Kroll
The zebrafish as a model organism to study vascular differentiation and remodeling