SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

Prof. Dr. Ingrid Fleming Institute for Vascular Signalling Centre for Molecular Medicine Goethe University Theodor Stern-Kai 7 D-60590 Frankfurt Phone: 0049 (0)69 6301 6972 or -6052 Lab Homepage
	fleming(at)em.uni-frankfurt.de
A6: Molecular analysis of cytochrome P450 epoxygenases as regulators of angiogenic endothelial cell signalling and vascular differentiation
The major aims of this project are to clarify the mechanisms underlying angiogenesis and vascular stabilization by cytochrome P450 (CYP)-derived products, to determine the contribution of endothelial cells as well as monocyte/macrophages to this response, and to clarify the role of the soluble epoxide hydrolase (sEH). To achieve these goals we plan to concentrate on the signaling initiated by bioactive fatty acids generated/metabolized by 3 enzyme families in the CYP epoxygenase/epoxide hydrolase cascade, namely; the endothelial CYP2C epoxygenases, CYP2S1 which we have identified in macrophages, and the sEH.