The major aims of this project are to clarify the mechanisms underlying angiogenesis and vascular
stabilization by the cytochrome P450 (CYP)/soluble epoxide hydrolase (sEH) axis. To achieve these
goals we plan to concentrate on the signalling (Notch, Wnt, G protein-coupled receptors) initiated by
bioactive fatty acids (CYP-derived epoxides and sEH-derived diols) generated/metabolized by three
enzyme families, namely; the CYP epoxygenases Cyp2c44 and CYP2S1 as well as the sEH.