SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

Dr. Marina Schorpp-Kistner and Prof. Dr. Peter Angel ZMBH-DKFZ Alliance Signaltransduktion und Wachstumskontrolle A100 Im Neuenheimer Feld 280 D-69120 Heidelberg Phone: 0049 (0) 6221 42 4575 / 4570 Lab Homepage
	marina.schorpp(at)dkfz-heidelberg.de p.angel(at)dkfz.de
B2: Role of Junb and Junb target genes in vascular morphogenesis and homeostasis
In the past, we established Junb as a critical regulator of angiogenic processes and in vessel contractility. Recently, we found that Junb controls expression of microRNAs including miR-182. Importantly, Junb and its target miR-182 are required for lymphangiogenesis in the zebrafish. In continuation of this work, we will (1) identify downstream targets and study to the impact of the JunbmiR- 182 axis in mammalian lymphangiogenesis, (2) investigate the role of novel Junb-induced microRNAs in vascular processes in the zebrafish, and (3) decipher the mode of Junb-dependent suppression of known angiomirs.

Summary of newly identified direct Junb target genes that are induced in response to hypoxia
via Junb and that have important functions in angiogenic processes.