In the past, we established Junb as a critical regulator of angiogenic processes and in vessel
contractility. Recently, we found that Junb controls expression of microRNAs including miR-182.
Importantly, Junb and its target miR-182 are required for lymphangiogenesis in the zebrafish. In
continuation of this work, we will (1) identify downstream targets and study to the impact of the JunbmiR-
182 axis in mammalian lymphangiogenesis, (2) investigate the role of novel Junb-induced
microRNAs in vascular processes in the zebrafish, and (3) decipher the mode of Junb-dependent
suppression of known angiomirs.