SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

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Dr. Marina Schorpp-Kistner and
Prof. Dr. Peter Angel

ZMBH-DKFZ Alliance
Signaltransduktion und Wachstumskontrolle A100
Im Neuenheimer Feld 280
D-69120 Heidelberg

Phone: 0049 (0) 6221 42 4575 / 4570

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B2: Role of Junb and Junb target genes in vascular morphogenesis and homeostasis
In the past, we established Junb as a critical regulator of angiogenic processes and in vessel contractility. Recently, we found that Junb controls expression of microRNAs including miR-182. Importantly, Junb and its target miR-182 are required for lymphangiogenesis in the zebrafish. In continuation of this work, we will (1) identify downstream targets and study to the impact of the JunbmiR- 182 axis in mammalian lymphangiogenesis, (2) investigate the role of novel Junb-induced microRNAs in vascular processes in the zebrafish, and (3) decipher the mode of Junb-dependent suppression of known angiomirs.

Summary of newly identified direct Junb target genes that are induced in response to hypoxia
via Junb and that have important functions in angiogenic processes.

Last update: July 2013