SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

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Prof. Dr. Sergij Goerdt and
Dr. Cyrill Géraud

Universitätsmedizin Mannheim
Klinik für Dermatologie
Theodor-Kutzer-Ufer 1-3
D-68167 Mannheim

Phone: 0049 (0) 621 383 2280

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B1: Liver-specific vascular differentiation and function
Liver-sinusoidal endothelial cells (LSEC) play an essential role as protective scavenger cells for the whole organism as stabilin-1/2-deficient mice show severe organ dysfunction. Comprehensive molecular analyses revealed several functional gene clusters including transcription factors such as GATA4 to determine the organ-specific differentiation program of LSEC. The major aim for the next funding period is to investigate hepatic endothelial differentiation and reprogramming. To this end the inter-connective network of transcription factors, miRNAs, signalling pathways and their target genes in LSEC differentiation and their impact on LSEC functions will be analysed. To study decisive LSEC genes such as Gata-4 and BMP2 in liver biology and pathology in vivo, a LSEC-specific (stab2) Credeleter mouse will be generated.
Last update: July 2013