SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

Dr. Yvonne Reiss and Prof. Dr. Karl H. Plate Institute of Neurology/Edinger Institute Frankfurt University Medical School Heinrich-Hoffmann-Str. 7 D-60528 Frankfurt Phone: 0049 (0)69 6301 84155 Lab Homepage
	yvonne.reiss(at)kgu.de karl-heinz.plate(at)kgu.de
C1: Influence of Angiopoietin-2 on vascular integrity and accessory cell recruitment
Angiopoietin-2 (Ang-2) is highly upregulated during pathological angiogenesis and antagonizes the actions of Ang-1, as such allowing new vessels to sprout. Using the limb ischemic model we recently showed that Ang-2 dosage is important. However, the molecular mechanisms of Ang-2-mediated neovessel formation has only been started to be analyzed. Therefore, within the next funding period of the SFB/TR23 we plan to decipher in detail the in vivo functions of Ang-2 on endothelial integrity and the recruitment of accessory cells during tumor angiogenesis using a transgenic mouse model with inducible endothelial-specific Angiopoietin-2 expression.