SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

PD Dr. Nina Wettschureck and Prof. Dr. Stefan Offermanns Max-Planck-Institut für Herz- und Lungenforschung Abteilung Pharmakologie Ludwigstr. 43 D-61231 Bad Nauheim Phone: 0049 (0)6032 705 1214 Lab Homepage
	nina.wettschureck(at)mpi-bn.mpg.de stefan.offermanns(at)mpi-bn.mpg.de
C7: Mechanisms of platelet activation and their relevance for platelet / vessel wall interaction
Platelets do not only play a role in haemostasis and thrombosis, they also have been suggested to contribute to the development of chronic vascular diseases. The goal of this project is to dissect the molecular mechanisms underlying distinct platelet functions, and to understand the contribution of these platelet functions to vascular remodeling. To achieve these goals, we will analyze mice carrying defined platelet defects with respect to atherosclerosis development, neointima formation, or angiogenesis. In parallel, we will set up a siRNA screen for in vitro-generated platelets to identify new signaling components regulating specific platelet functions.

Signalling pathways in activated platelets. ADP, adenosine diphosphate; DAG, diacyl glycerol;
Fb, fibrinogen, GP-IIb/IIIa, glycoprotein IIb/IIIa; IP3, inositol-1,4,5-trisphosphate; PKC, protein kinase C;
PLC-b, b-isoforms of phospholipase C; TXA2, thromboxane A2.