SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

PD Dr. Jens Kroll Vascular Biology, Center for Biomedicine and Medical Technology (CBTM), Medical Faculty Mannheim, Heidelberg University Ludolf-Krehl-Str. 13-17 D-68167 Mannheim Phone: 0049 (0)621 383 9965 Lab Homepage
	jens.kroll(at)medma.uni-heidelberg.de
Z5: The zebrafish as a model organism to study vascular differentiation and remodeling
The zebrafish model is a powerful tool to study vascular differentiation and remodeling. We have established a zebrafish unit at the CBT Mannheim that offers different fish lines for expression studies and we are performing injections of morpholinos and mRNAs for loss-of-function and gain-of-function experiments. In the next funding period we are planning to improve imaging techniques, we will establish test systems to analyze pharmacological substances and growth factors and we will set up tumor cell injections to study tumor angiogenesis in zebrafish. Thus, this service project will provide an attractive platform to study the vasculature in zebrafish.