The zebrafish model is a powerful tool to study processes of vascular differentiation and remodeling in
vivo. During the second funding period we have performed several expression studies, loss-of-function
and gain-of-function experiments in zebrafish including imaging for several SFB/TR23 investigators. In
the next funding period we will further offer the zebrafish model to analyze formation, function and
differentiation of the vasculature in vivo. We will advance and develop novel protocols including
generation of zebrafish mutants, expression analyses, imaging techniques and tumor cell injections.