SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

Prof. Dr. Thomas Wieland and Dr. Susanne Lutz Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Medizinischen Fakultät Mannheim Maybachstraße 14 D-68169 Mannheim Phone: 0049 (0)621 383 9610 Lab Homepage
	thomas.wieland(at)medma.uni-heidelberg.de susanne.lutz(at)medma.uni-heidelberg.de
B6: Endothelial RhoGEFs as regulators of angiogenesis
The activation of RhoGTPases, which is mediated by guanine nucleotide exchange factors (GEF), is a pivotal step in the angiogenic response of the endothelium to stimulation with vascular endothelial growth factor (VEGF) and angiotensin II. We recently identified two endo-thelial GEF subfamilies, the GEF10 and the p63RhoGEF subfamily, as potential mediators of the VEGF- and angiotensin II-induced RhoA activation in the vascular endothelium. The current project therefore characterizes the role of these GEFs in angiogenesis in vitro and in vivo.